Oxidative stress is one of the important factors that contribute to the pathogenesis of coronary heart disease (CHD). Sestrin2 is a stress-induced antioxidant protein that plays an important role in type 2 diabetes and CHD. A recent study published in ‘BMC Cardiovascular Disorders’ investigated the relationship between serum Sestrin2 levels and CHD in patients with type 2 diabetes indicates that Sestrin2 levels were highly associated with CHD in patients with diabetes.

The study cohort included 70 patients with both type 2 diabetes and CHD and 69 patients with type 2 diabetes. Clinical features and metabolic indices were identified. Serum Sestrin2 was measured by ELISA. Observations from the study had revealed that serum Sestrin2 levels in T2DM-CHD groups were significantly lower compared with the T2DM group (11.17 (9.79, 13.14) ng/mL vs 9.46 (8.34, 10.91) ng/mL). Bivariate correlation analysis revealed that serum Sestrin2 levels were negatively correlated with age, BMI, and Fasting Blood Glucose (FBG).

The researchers opined that Sestrin2 can be a risk factor that can play a significant role in the process of developing T2DM with CHD.