Research on the impact of maintaining Time-in-range in individuals with type 1 diabetes shows that it can even influence the daily mood of individuals. The study was published in ‘Journal of Diabetes and its Complications’. The research conducted in a cohort of 219 T1D adults, all currently on a real-time continuous glucose monitoring system (RT-CGM), to evaluate how daily changes in CGM metrics were associated with nightly reports of positive and negative mood over a two-week period.

      The results from the study revealed that greater the time spent in TIR (70–180mg/dL) and less time in "severe" hyperglycemia (TAR>300mg/dL) both were significantly associated with higher ratings on all positive mood elements and lower ratings on most negative mood elements (all ps<0.05). When %TIR and %TAR considered together as predictors, %TIR but not %TAR >300 emerged as an independent predictor of many of the positive and negative mood variables. Neither daily changes in time spent in hypoglycemia (<70mg/dL) nor glycemic variability (represented by the coefficient of variation) were significantly related to reported mood.

      With these observations, the researchers had put forth the concluding remark that study provides the first evidence that time in range (%TIR) is associated with, and likely enhances, daily mood. Also, consistent with previous studies, the authors found that the more time spent in severe hyperglycemia is linked to more negative mood.