This study was presented at the 11th JPEF Annual Diabetes Convention organized by Jothydev’s Diabetes Research Centre in Trivandrum and received the first prize among oral presentations.

      The objective of the study was to assess the effect of the critical balance between plasma Sfrp5 and Wnt5a levels and to determine the correlation of individual plasma Sfrp5 and Wnt5a levels with the risk factors of prediabetes.

      Patients registered in the OPD of the Department of Medicine were enrolled in this study based on specific inclusion and exclusion criteria. The study included 50 people diagnosed with prediabetes and 50 healthy controls. People aged between 18 and 70 years and with blood pressure greater than 140/90 mmHg were eligible for participation. Anthropometric measurements such as blood pressure (BP), body mass index (BMI), waist circumference (WC), and biochemical parameters including fasting plasma glucose (FPG) and lipid profile were measured for each enrolled patient. Lipid profile was analyzed using the selectra autoanalyzer and relevant kits, while blood glucose levels were estimated using the GOD-POD method.

      The study revealed that serum Sfrp5 level was significantly lower in people with prediabetes compared to control subjects. However, Wnt5a level was found to be non-significant in both cases and controls. The results provide clinical evidence that the downregulation of Sfrp5 might play a potential role in the pathogenesis of prediabetes.