The FDA has approved Advantame, a high-intensity sweetener developed by Japanese food and chemical corporation, Ajinomoto for general use in foods and beverages. Advantame is also FEMA GRAS approved in Dairy, Frozen Desserts, Beverages, and Chewing Gum. Advantame is the sixth artificial sweetener to be approved by the FDA and is a white powder derived from aspartame and vanillin that dissolves in water, and continues to remain stable in high temperatures.

The director of the FDA's Division of Petition Review and the US Public Health Service, Captain Andrew Zajac, stated "sugar substitutes are called 'high intensity' because small amounts pack a large punch when it comes to sweetness." It is understood that artificial high-intensity sweeteners add little or no calories to a diet, and usually do not raise blood glucose levels in patients.

Advantame received consent to be used as a tabletop sweetener or as an ingredient for cooking purposes. The FDA based its approval on the results of 37 human and animal studies submitted by the manufacturer. The safety studies were designed to identify possible toxic effects, such as reproductive, neurological, and cancer-causing effects. The FDA concluded after a thorough evaluation that advantame is safe for human consumption under the petitioned conditions of use.