There is no previous study, which has examined the association between egg consumption and type 2 diabetes, though there are previous studies associating dietary cholesterol with egg intake. A study conducted under the leadership of Luc Djoussé with the help of different medical institutions in Massachusetts examined the relation between egg intake and the risk of type 2 diabetes in two large prospective cohorts.

In this prospective study, they used data from two completed randomized trials: 20,703 men from the Physicians' Health Study I (1982–2007) and 36,295 women from the Women's Health Study (1992–2007). Egg consumption was ascertained using questionnaires, and used the Cox proportional hazard model to estimate relative risks of type 2 diabetes. This study suggest that high levels of egg consumption (daily) are associated with an increased risk of type 2 diabetes in men and women.