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| 7. Diabetes Medicine Updates |
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| Diabetes drug Metformin could also work against Alzheimer's | |||
German scientists found that diabetes drug metformin has a potential to work against Alzheimer's diseases. The animal study results showed that metformin counteracts alterations of the cell structure protein Tau in mice nerve cells. These alterations are a main cause of the Alzheimer's disease. Moreover, they uncovered the molecular mechanism of metformin in this process. Their results have been published in the Proceedings of the National Academy of Sciences (Nov. 22, 2010). "If we can confirm that metformin is also effective in humans, it is certainly a good candidate for an effective therapy on Alzheimer's diseases," says Sybille Kraub from German Centre for Neurodegenerative Diseases (DZNE), the University of Dundee and the Max-Planck-Institute for Molecular Genetics. |
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| Bromocriptine in T2 Diabetes. | |||
| Recently US FDA has approved bromocriptine for use in T2diabetes.Bromocriptine is not a new molecule. It has been popular in neurology. However, in diabetes it is now proven to increase insulin sensitivity, reduce both fasting and postprandial sugar levels, reduce hepatic glucose production, decrease adipose lipolysis and it improves the suppression of hepatic glucose out put. Bromocriptine unlike other oral medicines in diabetes, acts by a novel mechanism. It is a D2 receptor agonist and increases dopaminergic activity at the day time. In other words it resets the normal circadian rhythm of the body. |
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