Myo-inositol hexaphosphate (Phytate or InsP6), a phytochemical found in cereals, legumes, and nuts, has been shown to offer varied benefits to patients with type 2 diabetes mellitus (T2DM). A recent randomized crossover trial published in 'Diabetes and Nutrition' investigated the impact of daily consumption of InsP6 on serum levels of inflammatory markers, including adiponectin, TNF-alpha, IL-6, and IL-1beta, in T2DM patients (n = 39).

      The trial involved measuring serum levels of the inflammatory markers, classic vascular risk factors, and urinary InsP6 at baseline and at the end of the intervention period. Results indicated that patients who consumed InsP6 supplements for 3 months had higher levels of adiponectin and lower HbA1c than those who did not consume InsP6.

      The researchers noted that this was the first report to demonstrate that InsP6 consumption can increase plasma adiponectin concentration in patients with T2DM. This finding has important implications for the prevention and minimization of diabetic-related complications. The study suggests that daily consumption of InsP6 may be a useful strategy to improve glycemic control and reduce inflammation in T2DM patients. Further research is needed to confirm these findings and explore the potential mechanisms underlying the effects of InsP6 on T2DM.